Endocrine Abstracts

Introduction: Transsphenoidal surgery (TSS) is the treatment option of first choice for Cushing’s disease (CD). The traditional microsurgical technique has recently been challenged by endoscopic surgical methods. We present endocrine outcome of TSS in CD with a modified contemporary microsurgical concept.Methods: Eighty three patients underwent TSS for newly-diagnosed CD (72 microadenomas and 11 macroadenomas). An enlarged resection was performed in...

Objective: In part I of the study a health related quality of life (HRQoL) inventory for Cushing’s disease (CD), the Tuebingen Cushing-25 quality of life inventory (Tuebingen CD-25) was developed. In the second part, we assessed normative data from healthy controls (HC) with which the individual patients’ scores can be compared.Methods: Sources for item generation consisted of technical literature, interviews with patients and the rating of neu...